P0301 Ram 1500: Cylinder 1 Misfire Causes

2009-2024 Ram 1500
P0301
Cylinder 1 Misfire - Ram 1500
On the Ram 1500, P0301 on the 5.7L Hemi typically means an MDS lifter has collapsed - cyl 1 is MDS-active. $120-$3,500 fix range.
Moderate Severity $80-$3,500 Repair Range Vehicle-Specific Pattern
Plain English

What P0301 means for your Ram 1500

Your Ram 1500's PCM caught cyl 1 misfiring. On the 5.7L Hemi, Chrysler's Multi-Displacement System (MDS) deactivates cylinders 1, 4, 6, and 7 under cruise. The MDS lifters on these cylinders are the single most common Hemi failure - they collapse, often bending a pushrod and damaging the cam lobe. On the 3.6L Pentastar, P0301 is usually a coil or the left-bank rocker assembly. The 6.4L 392 doesn't have MDS so it's almost always a coil there.

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Top Causes of P0301 on the Ram 1500

50%
#1 CAUSE
Collapsed MDS Lifter (5.7L Hemi cyl 1, 4, 6, or 7)
The 5.7L Hemi MDS deactivates cyls 1, 4, 6, 7. The MDS lifter on cyl 1 collapses and stays collapsed, often bending a pushrod or wearing the cam lobe. Symptoms: P0301 + metallic tick at idle + rough cold start. Once a pushrod bends you need the head off. Most Ram owners do an MDS delete during the lifter job to prevent recurrence on cyls 4, 6, 7.
Lifter + Pushrod
$1,800-$3,500
MDS Delete Kit
$650-$1,300
Cam if damaged
$2,500-$5,500
25%
#2 CAUSE
Cylinder 1 COP Coil Failure
5.7L Hemi has 16 spark plugs (2 per cylinder) and 8 coils. Cyl 1 coil is driver side, front - easy access. Pentastar V6 also uses individual COPs. Replace with Mopar 56028394AB (Hemi) or 4606824AC (Pentastar).
OEM Coil
$70-$120
Aftermarket
$28-$55
w/Labor
$120-$220
15%
#3 CAUSE
Spark Plug Set Worn (Hemi uses 16 plugs!)
Hemis use TWO plugs per cylinder for completeness of combustion. Spec is NGK ZFR5LP-13G at 30k-100k depending on year. Cyl 1 fouls first. Always replace all 16. People who do half (8 only) get repeat misfires. Pentastar V6 uses 6 plugs.
Plugs Hemi (16)
$80-$140
w/Labor
$280-$520
Pentastar (6)
$40-$85

Most Affected 1500 Model Years

YearEnginePrimary CauseTypical MileageNotes
2009-20135.7L Hemi (MDS)MDS lifter / coil80k-160kCyl 1 is MDS-active
2014-20185.7L Hemi (MDS) / 3.6L PentastarMDS lifter60k-140kMDS lifter peak failure window
2019-20245.7L eTorque / Pentastar / 3.0 EcoDieselMDS lifter / coil40k-120keTorque adds 48V mild hybrid
2015-20246.4L 392 HemiCoil pack #160k-140kNo MDS - coil failures only
TSB info: Chrysler TSB 09-001-15 (Hemi MDS lifter inspection); aftermarket MDS delete kits from Comp Cams, Hellwig, Edelbrock are the de-facto permanent fix.

How to Diagnose P0301 on a Ram 1500

  • Listen at idle. Tick + P0301 on a 5.7L Hemi = MDS lifter collapse. Skip the coil swap and pull the valve cover to check the cyl 1 pushrod for bend.
  • No tick? Swap coil 1 with coil 3 and drive 20 miles. If code follows the coil, replace it.
  • If you confirm MDS lifter failure, install an MDS delete kit during the repair (non-MDS lifters, blocker plate, ECM tune). Cylinders 1, 4, 6, 7 all share the same flawed MDS hardware - one failure means more are coming.
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P0301 Ram 1500 FAQs

How do I know if it's an MDS lifter on my Hemi?
Listen for a metallic tick at idle, plus rough cold start. A coil swap takes 5 minutes - if the code follows the coil it's not MDS. If the swap does nothing and you hear a tick, pull the valve cover and check pushrods 1, 4, 6, 7 for bend.
Should I do an MDS delete on a 5.7L Hemi?
If you've had one MDS lifter fail, absolutely. The other three MDS cylinders (1, 4, 6, 7) share the same hardware - one failure usually means more are coming. Adding the delete during the lifter job costs $650-$1,300 extra and prevents three more $2,500 repairs.
What does P0301 cost to fix on a Ram 1500?
5.7L Hemi coil swap: $120-$220 shop. Full plug set (16 plugs!): $280-$520. MDS lifter collapse: $1,800-$3,500 - or $2,500-$5,500 if the cam lobe got chewed.
Is the 6.4L 392 better than the 5.7L Hemi for P0301?
Yes - the 6.4L doesn't have MDS, so it never has the catastrophic lifter-failure issue. The 392's only common P0301 cause is a coil pack, which is a 5-minute fix.

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